第五届留芬华人生命科学学术年会于2011年10月14日在芬兰赫尔辛基生物医学研究中心隆重召开，来自芬兰各地的近80名专家学者参加了本届年会。本次 年会邀请了近期在生命科学领域成果突出的芬兰专家与留芬华人学者共同研讨，切实增进了中芬两国生命科学领域专家学者的学术交流。

年会组委会主席李松平博士，芬兰癌症生物学核心项目执行主任Jorma Keski-Oja教授分别致开幕词。芬兰Jyv?skyl?大学程蜀琳教授，赫尔辛基大学Jukka Corander教授，图尔库国家健康福利研究中心何秋水副教授，欧盟研究委员会独立研究员Ville Hietakangas副教授，赫尔辛基大学神经科学中心田莉副教授，赫尔辛基生物医学芯片中心Outi Monni副教授，奥卢大学生物科学中心卫功宏博士等十余名专家做了专题报告。华大基因欧洲分部的胡劲之先生向大家介绍了华大基因在北欧的运作和发展愿 景。

会议报告涉及生理学，分子生物学，植物学，免疫学，遗传学，生物信 息与生物统计学等多个方向，形成生命科学领域的跨方向学术交流。与会专家分别介绍了各自的最新科研成果和技术，参会学者对每个报告进行了深入严谨的探讨。 整场会议气氛活跃，拓展了年轻学者的视野，加强了中芬学者之间的学术互动，为中芬学者之间的科研合作打下良好基础。

本届会议得到了中国驻芬兰使馆教育组、华大基因欧洲分部 和芬兰ORION制药等单位的大力支持。

中国驻芬使馆科技组张新民博士代表中国驻芬兰大使馆致闭幕词。他总结了本届会议的学术成果，指出华人生命科学学者在芬发展的良好态势，同时勉励华人留学生 和年轻学者以成就丰硕的前辈学者为榜样，脚踏实地，刻苦钻研，为中芬两国生命科学领域的发展做出贡献。

年会组委会
学术协调： 李松平， 卫功宏
组委会成员：
陈平，程芳，程路，方慎彤， 冯琳，胡益洲，江淼， 柳成宇，刘颖，马莉，魏静，颜彦，郑玮，周游.

第五届留芬华人生命科学年会

时间： 2011/10/14, 12:00-18:00
地点：Lecture Hall 3, Biomedicum Helsinki
(Haartmaninkatu 8 , Helsinki)

目前会议注册正式开放，欢迎大家参加并交流。

本次年会面向生命科学相关领域或者对生命科学领域感兴趣的所有硕士生，博士生，学者老师。年会包括半天的学术讲座和午餐（或者晚餐）聚会。同时，我们欢迎大家提交学术摘要供彼此相互交流，我们将从摘要中选取数名演讲者做 short talk.

由于座位有限，请有意参会的学生学者尽快报名。

注册截止日：2011年10月6日

部分演讲者信息：http://www.calsif.org/3/post/2011/09/speakers-of-5th-calsif-annual-meeting.html

注册链接：http://www.calsif.org/5th-calsif-annual-meeting.html

 

Registration Opened：5th CALSiF Annual Meeting

October 14th, 2011,12:00-18:00

Lecture Hall 3, Biomedicum Helsinki, Finland

This meeting is intended for master students, graduate students and senior scientists interested in life science. There will be half day of talks by Chinese and Finnish scientists of life science with excellent achievements recently, and a symposium lunch or dinner.

Registration deadline is October 6th, 2011.

Selected Speaker Information: http://www.calsif.org/3/post/2011/09/speakers-of-5th-calsif-annual-meeting.html

Registration form: http://www.calsif.org/5th-calsif-annual-meeting.html

He Qiushui, MD, PhD
Laboratory Director and Docent
National Institute for Health and Welfare, Turku, Finland
 
Research field：Infectious Disease, Infection biology, Bacterial genomics, 
Vaccine, Medical Microbiology, Diagnosis

Jukka Corander
                    
PhD, Professor

Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland

Research field: statistical genetics, bioinformatics, graphical models, stochastic simulation, machine learning, theory of classification.

Selected publications:

Lu Cheng, Thomas R Connor, David M Aanensen, Brian G Spratt and Jukka Corander. (2011) Bayesian semi-supervised classification of bacterial samples using MLST databases. BMC Bioinformatics, 12:302.
Marttinen P and Corander J. (2010) Efficient Bayesian approach for multilocus association mapping including gene-gene interactions. BMC Bioinformatics, 11:443.
Marttinen P, Corander J (2009). Bayesian learning of graphical vector autoregressions with unequal lag-lengths. Machine Learning, 75, 217-243.
Hanage WP, Fraser C, Tang J, Connor T, Corander J. (2009). Hyper-recombination, diversity and antibiotic resistance in the pneumococcus. Science, 324, 1454-1457.
Tang J, Hanage WP, Fraser C, Corander J. (2009). Identifying currents in the gene pool for bacterial populations using an integrative approach. PLoS Computational Biology, 5(8): e1000455.
Marttinen P, Baldwin A, Hanage WP, Dowson C, Mahenthiralingam E, Corander J (2008). Bayesian modeling of recombination events in bacterial populations. BMC Bioinformatics 9:421.

Ville Hietakangas

PhD, Academy Research Fellow
Institute of Biotechnology, University of Helsinki
Research field: Signaling in growth and metabolism
webpage：http://hietakangas.biocenter.helsinki.fi/
Selected publications:

Hietakangas V & Cohen SM. Regulation of tissue growth through nutrient sensing. Annu. Rev. Genet. 2009.43:389-410. Review.
Szuplewski S, Sandmann T, Hietakangas V & Cohen SM. Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev. 2009. 23: 1998-2003.
Hietakangas V  & Cohen SM. TOR complex 2 is needed for cell cycle progression and anchorage-independent growth in MCF7 and PC3 tumor cells. BMC Cancer 2008. 8:282.
Teleman AA*, Hietakangas V*, Sayadian AC & Cohen SM.  Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 2008. 7: 21-32.
Hietakangas V & Cohen SM. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth.Genes Dev. 2007. 21: 632-637.
Blomster HA, Hietakangas V, Kouvonen P, Wu J, Hautaniemi S & Sistonen L. Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites. Mol Cell Proteomics. 2009 Jun;8(6):1382-90.
Hietakangas V*, Anckar J*, Blomster HA, Fujimoto M, Palvimo JJ, Nakai A & Sistonen L. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. USA. 2006. 103: 45-50.
Anckar J*, Hietakangas V*, Denessiouk K, Thiele DJ, Johnson MS & Sistonen L. Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol. Cell. Biol. 2006. 26:955-964.
Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A,  Palvimo JJ, Pirkkala L & Sistonen L. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol. Cell. Biol. 2003. 23:2953-2968.

 Li  Tian

MD, PhD,  Docent, Academy Research Fellow
Neuroscience Center, University of Helsinki, Helsinki, Finland
Research field: Neural regulation of innate and Adaptive immunity

Selected publications:

Tian, L., Rauvala, H., Gahmberg, C. G. (2009) Regulation of CNS immune responses by neurons. Trends in Immunol. 30 (2): 91-9.   

Tian, L., Lappalainen, J., Autero, M., Häninen, S., Rauvala, H., Gahmberg, C. G. (2008) Soluble ICAM-5 downregulates TCR-mediated T cell activation. Blood 111(7): 3615-25.

Tian, L., Stefanidakis, M., Ning, L., Van Lint, P., Libert, C., Itohara, S., Masayoshi, M., Rauvala, H., Gahmberg, C. G. (2007) Activation of NMDA receptors promotes dendritic spine development through MMP-mediated cleavage of ICAM-5. J. Cell Biol. 178: 687-700.

Gahmberg CG, Tian L, Ning L, Nyman-Huttunen H.(2008) ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain. Immunol Lett.  May 15;117(2):131-5.

Kaisa Lehti
PhD, Academy Research Fellow
Genome-Scale Biology Research Program, Faculty of Medicine, University of Helsinki
Research field：Signals and effectors of tissue invasion

Selected publications:

Sugiyama N., Varjosalo M., Meller P., Lohi J., Chan K.M., Zhou Z., Alitalo K., Taipale J., Keski-Oja J. and Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane-type-1 matrix metalloproteinase-FGFR4 complex. PNAS. 107: 15786-15791, 2010.
Sugiyama N., Varjosalo M., Meller P., Lohi J., Hyytiäinen M., Kilpinen S., Kallioniemi O., Ingvarsen S., Engelholm L. H., Taipale J., Alitalo K., Keski-Oja J. and Lehti K. Fibroblast growth factor receptor-4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Res. 70:7851-7861, 2010.
Lehti, K., Rose, N., Valavaara, S., Weiss S.J., and Keski-Oja, J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J. Cell Science. 122: 126-135, 2009.
Lehti, K., Allen, E., Holmbeck, K., Birkedal-Hansen, H., Miyake, Y., Chun, T., and Weiss S.J.  MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculature. Gene & Dev. 19: 979-991, 2005.
Lehti, K., Lohi, J., Juntunen, M., Pei, D., and Keski-Oja, J. Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP). J. Biol. Chem. 277: 8440-8448, 2002.
Jiang, A., Lehti, K., Wang, X., Weiss, S. J., Keski-Oja, J., and Pei, D. Regulation of Membrane-type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis. PNAS. 98: 13693-13698, 2001.
Lehti, K., Valtanen, H., Wickström S., Lohi, J., and Keski-Oja, J. Regulation of membrane-type-1 matrix metalloproteinase (MT1-MMP) activity by its cytoplasmic domain. J. Biol. Chem. 275: 15006-15013, 2000.

Jing Li
                    
PhD, Docent

Affiliation: Faculty of Biological & Environmental Sciences, University of Helsinki

Research field: Plant innate immunity

Link: http://my.aspb.org/resource/resmgr/docs/aspbtopauthors.pdf

Outi Monni

PhD, Docent, Academy Research Fellow
Genome-Scale Biology Research Program, Biomedicum Helsinki.
Research field: Oncogenomics

Selected publications:

Junnila S, Kokkola A, Karjalainen-Lindsberg ML, Puolakkainen P, Monni O. Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines. BMC Cancer. 2010 Mar 1;10:73.
Chen P, Lepikhova T, Hu Y, Monni O, Hautaniemi S. Comprehensive exon array data processing method for quantitative analysis of alternative spliced variants. Nucleic Acids Res. 2011 Jul 10. [Epub ahead of print]
Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi S,
Monni O. Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC Genomics 9:348, 2008.
Myllykangas S, Junnila S, Kokkola A, Autio R, Scheinin I, Karjalainen-Lindsberg M-L, Kiviluoto T, Hollmén J, Knuutila S, Puolakkainen P, Monni O. Integrated gene copy number and expression microarray analysis of gastric cancer highlights potential target genes. Int J Cancer 123:817-825, 2008.
Järvinen AK, Autio R, Haapa-Paananen S, Wolf M, Saarela M, Leivo I, Grénman R, Kallioniemi O, Mäkitie AA, Monni O . Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. Oncogene 2006; 25:6997-7008.
Hautaniemi S, Edgren H, Vesanen P, Wolf M, Järvinen AK, Yli-Harja O, Astola J, Kallioniemi O, Monni O . A novel strategy for microarray quality control using Bayesian networks. Bioinformatics 2003; 19:2031-2038.
Hyman E, Kauraniemi P, Hautaniemi S, Wolf M., Mousses S, Rozenblum E, Ringnér M, Sauter G, Monni O , Elkahloun A, Kallioniemi A, Kallioniemi OP. Impact of DNA amplification on gene expression patterns in breast cancer, Cancer Res 2002; 62:6240-6245.
Monni O , Bärlund M, Mousses S, Kononen J, Sauter G, Heiskanen M, Paavola P, Avela K, Chen Y, Bittner M L, Kallioniemi A: Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer. P Natl Acad Sci USA 2001; 98:5711-5716.

Gonghong Wei
PhD, Junior Investigator
Biocenter Oulu and Deparment of Medical Biochemistry and Molecular Biology
Research field：gene regulation and regulatory genomics

Selected publications:

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.
Wei GH, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J.
EMBO J. 2010 Jul 7;29(13):2147-60. Epub 2010 Jun 1.

Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.
Jolma A, Kivioja T, Toivonen J, Cheng L, Wei G, Enge M, Taipale M, Vaquerizas JM, Yan J, Sillanpää MJ, Bonke M, Palin K, Talukder S, Hughes TR, Luscombe NM, Ukkonen E, Taipale J.
Genome Res. 2010 Jun;20(6):861-73. Epub 2010 Apr 8.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.
Tuupanen S, Turunen M, Lehtonen R, Hallikas O, Vanharanta S, Kivioja T, Björklund M, Wei G, Yan J, Niittymäki I, Mecklin JP, Järvinen H, Ristimäki A, Di-Bernardo M, East P, Carvajal-Carmona L, Houlston RS, Tomlinson I, Palin K, Ukkonen E, Karhu A, Taipale J, Aaltonen LA. Nat Genet. 2009 Aug;41(8):885-90. Epub 2009 Jun 28.

Chromatin domain boundaries: insulators and beyond.
Wei GH, Liu DP, Liang CC. Cell Research. 2005 Apr;15(4):292-300.

Charting gene regulatory networks: strategies, challenges and perspectives.
Wei GH, Liu DP, Liang CC. Biochem Journal. 2004 Jul 1;381(Pt 1):1-12.

Mechanisms of human gamma-globin transcriptional induction by apicidin involves p38 signaling to chromatin.
Wei GH, Zhao GW, Song W, Hao DL, Lv X, Liu DP, Liang CC. Biochem Biophys Res Commun. 2007 Nov 30;363(4):889-94. Epub 2007 Aug 1.

Zhang Fuping           

MD, PhD, Docent

Turku Center for Disease Modeling, University of Turku, Turku, Finland
Research field: Molecular Biology, Reproductive Biology, Mouse Biology and Genetics

Selected publications:

Pihlajamaa P, Zhang FP, Saarinen L, Mikkonen L, Hautaniemi S, Jänne OA. The Phytoestrogen Genistein Is a Tissue-Specific Androgen Receptor Modulator. Endocrinology. 2011 Aug 30. [Epub ahead of print]
Zhang FP, Mikkonen L, Toppari J, Palvimo JJ, Thesleff I, Jänne OA.Sumo-1 function is dispensable in normal mouse development. Mol Cell Biol. 2008 Sep;28(17):5381-90. Epub 2008 Jun 23.
Zhang FP, Domanskyi A, Palvimo JJ, Sariola H, Partanen J, Jänne OA. An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation. Mol Endocrinol. 2007 Jun;21(6):1430-42.
Pakarainen T, Zhang FP, Poutanen M, Huhtaniemi I. Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action. J Clin Invest. 2005 Jul;115(7):1862-8. Epub 2005 Jun 9.
Zhang FP, Pakarainen T, Poutanen M, Toppari J, Huhtaniemi I. The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13692-7. Epub 2003 Oct 29.
Kero J, Poutanen M, Zhang FP, Rahman N, McNicol AM, Nilson JH, Keri RA, Huhtaniemi IT. Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. J Clin Invest. 2000 Mar;105(5):633-41

Jorma Keski-Oja
M.D., Ph.D., Professor
Molecular Cancer Biology Program , Biomedicum Helsinki, Haartman Institute
Research Field: Transforming Growth Factor Beta and Extracellular regulation in Cancer

Selected publications:
     
Vehviläinen P, Koli K, Myllärniemi M, Lindholm P, Soini Y, Salmenkivi K, Kinnula VL, Keski-Oja J. Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesothelioma. Hum Pathol. 2011 Feb;42(2):269-78. Epub 2010 Nov 24.

Chan SH, Yee Ko JM, Chan KW, Chan YP, Tao Q, Hyytiainen M, Keski-Oja J, Law S, Srivastava G, Tang J, Tsao SW, Chen H, Stanbridge EJ, Lung ML. The ECM protein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome. Int J Cancer. 2011 Aug 1;129(3):565-73. doi: 10.1002/ijc.25698. Epub 2010 Nov 9.

Sugiyama N., Varjosalo M., Meller P., Lohi J., Chan K.M., Zhou Z., Alitalo K., Taipale J., Keski-Oja J. and Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane-type-1 matrix metalloproteinase-FGFR4 complex. PNAS. 107: 15786-15791, 2010.

Sugiyama N., Varjosalo M., Meller P., Lohi J., Hyytiäinen M., Kilpinen S., Kallioniemi O., Ingvarsen S., Engelholm L. H., Taipale J., Alitalo K., Keski-Oja J. and Lehti K. Fibroblast growth factor receptor-4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. Cancer Res. 70:7851-7861, 2010.

 Vehviläinen, P., Hyytiäinen, M. and Keski-Oja, J.: Matrix association of latent TGF-bbinding protein-2 (LTBP-2) is dependent on fibrillin-1. J. Cell Physiol. 221: 586-593, 2009.

  Tritschler, I., Gramatzki, D., Capper, D., Mittelbronn, M., Saharinen, J., Wick, W., Keski-Oja, J., and Weller, M.: Modulation of TGF-b activation by latent TGF-b-binding protein 1 in human malignant glioma cells. Int. J. Cancer,125: 530-540, 2009.

  Manicone, A.M., Birkland T.P., Lin, M., Betsuyaku, T., van Roijen, N.,  Lohi,  J., Keski-Oja, J., Wang, Y., Skerrett, S.J. and Parks W.C.: Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J. Immunol. 182:3866-3876, 2009.

Hakulinen J., Sankkila, L., Sugiyama N., Lehti, K. and Keski-Oja, J.:   Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes, J. Cell. Biochem. 105: 1211-1218, 2008.

Koli, K., Ryynänen, M.J. and Keski-Oja, J.: Latent TGF-b binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.  Bone 43: 679-688, 2008.

  Tatti, O., Vehviläinen, P., Lehti, K., and Keski-Oja, J.: MT1-MMP releases latent TGF-b1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. Exp. Cell Res. 314: 2501-2514, 2008.

Myllärniemi M., Vuorinen, K., Pulkkinen, V., Kankaanranta, H., Aine, T., Salmenkivi, K., Keski-Oja, J. Koli, K., and Kinnula, V.L.:  Gremlin localisation and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. J. Pathol. 214: 456-463, 2008.

Keski-Oja, J.: Transforming growth factor beta. In: Enclycopedia of Cancer (M. Schwab, ed.), 2nd ed. Springer-Verlag, Berlin, Heidelberg, New York, 5 pp., 2008.

 llman, S.A., Lehti, K., Keski-Oja, J. and Lohi, J.: Epilysin (MMP-28) induces TGF-b mediated epithelial to mesenchymal transition in lung carcinoma cells. J. Cell Sci. 119: 3856-3865, 2006.

  Solovyan V.T. and Keski-Oja, J.: Apoptosis of human endothelial cells is accompanied by cleavage of latent TGF- b binding proteins and activation of TGF- b. Cell Death Differ. 12: 815-826 , 2005.

  Koli, K., Wempe, F., Sterner-Kock, A., Kantola, A., Komor, M., Hofman, W.-K., von Melchner, H. and Keski-Oja, J.: Disruption of LTBP-4 function reduces TGF- b activation and enhances BMP-4 signaling in the lung. J. Cell Biol., 167 : 123-133 , 2004.

  Wickström , S.A. , Alitalo, K., and Keski-Oja, J.: An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J. Biol. Chem. 279: 20178-20185, 2004.

Wang, X., Ma, D., Keski-Oja, J. and Pei , D.: Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network: Identification of DKV582 as a recycling signal. J. Biol. Chem. 279: 9331-9336, 2004.

Hyytiäinen, M. and Keski-Oja, J.: Latent TGF- b binding protein LTBP -2 decreases cell adhesion to fibronectin. J. Cell Biol. 163: 1363-1374, 2003.

Wickström SA, Keski-Oja J, Alitalo K.Matrix reloaded to circulation hits the tumor target. Cancer Cell. 2003 Jun;3(6):513-4.

Sterner-Kock, A., Thorey, I.S., Koli, K., Wempe, F., Kuhlmeier K., Otte, J., Bangsow, T., Kirchner, T., Jin, S., Keski-Oja, J. and von Melchner, H.: Disruption of the gene encoding the latent transforming growth factor-b binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy and colorectal cancer. Genes Dev. 16: 2264-2273, 2002.

Wickström S.A. , Alitalo, K. and Keski-Oja, J.: Endostatin associates with integrin a5b1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res. 62: 5580-5589, 2002.

2010年留芬华人生命科学协会学生学者共发表或参与发表文章共52篇，涵盖了分子生物学，细胞生物学，分子植物学，免疫学，预防医学，生理学，病理学， 系统生物学等多个领域，其中不少重要科研发现已经刊登在国际权威杂志上。汇总表中列出了每篇文章的 Title，Journal& Volume, Author Name, Link 以及 Abstract，详见协会内邮件组附件。
另外，我们也已经将近年来部分高水平文献以reference形式列入协会网站的selected-publications一栏中，欢迎大家查阅。


感谢各位老师和同学的积极支持与帮助！


2010CALSiF文献收集整理小组：胡益洲，程路，方慎彤，冯琳，马莉，孙小雨，周游，郑玮

留芬华人生命科学协会

二零一零年十二月三十一日

为增进协会成员对各自研究领域的了解，加强协会内部的学术交流，促进留芬华人生命科学工作者之间的技术合作，协会正收集整理2010年留芬华人发表的生命科学领域 学术文献，供各位老师同学参考。

作者资格：作者应为正在或曾经在芬兰学习工作的华人生命科学工作者
征集范围：征集文章为作者2010年发表或者参与发表的生命科学领域 学术文献（包括已接受的文章）
征集时间： 2010年12月7日起，预计12月中下旬整理完成在群邮件中公布，允许后续补充。
收件人邮箱：yizhou.hu@helsinki.fi

注：本次文献收集整理以加强学术了解为目的，以文献索引为形式。仅供留芬华人生命科学学生学者参考，不涉及盈利性质的活动。

From 中国科学院上海生命科学研究院
21世纪是生命科学的迅速发展的世纪，各项新的生物技术如干细胞技术、生物影像技术和病毒包装与转染技术的相继发现与深入研究，大大促进了现代生命 科学的前进步伐，并为进一步开展相关的生物医学转化型研究提供了理论基础。近年来，我国科学家在干细胞、免疫学、神经生物学等方面取得了较为突出的成绩， 尤其是上海生命科学研究院健康科学研究所在转化医学等领域取得了较好的成果。

为了加强国内外相关领域的了解和交流，尤其是进一步促进生命学研究新技术的深入发展及转化型研究的，召开高层次的研讨会就显得更为必要和及时。“第 一届中芬生命科学国际前沿研讨会”于2008年在武汉举行，由芬兰科学院、芬兰生物医学中心、上海生命科学研究院、苏州大学、武汉大学等单位联合举办，受 到了中芬两国专家、尤其是双方相关科研人员的一致好评，为双方专家学者提供了相互交流的平台。在此基础上，2009年在芬兰赫尔辛基成功举办了“第二届中 芬生命科学国际前沿研讨会”，进一步加强了中芬两国生命科学领域的合作和交流。随着各种生命科学研究新技术的不断成熟，第三届中芬生命科学国际研讨会将以 “生物技术和转化医学”（“Biotechnology & Translational Medicine”）。为主题，并拟定于2010年在上海召开。

我们将在上海市举办第三届中芬生命科学国际研讨会，相信本次会议的召开将进一步加强中芬双方的合作交流，并能够提升国内生命科学研究在国际的影响力。

会议议程 Programme

From Biocenter Viikki News


GENERAL INFORMATION The 2nd Sino-Finn Life Science Forum will be held in August 23 - 28, 2009 in Finland. This unique event is organised by Helsinki Graduate School of Biotechnology and Molecular Biology (GSBM) and Biocenter Finland Research Organisation. The event aims to promote bi-national research collaboration and training in biosciences between China and Finland and is a continuum to the First Sino-Finn Life Science Forum held in Wuhan, Suzhou and Shanghai in October 2008. 

Chinese Principal Investigators in the Universities of Wuhan, Suzhou, and Shanghai Institutes of Biological Sciences (Chinese Academy of Sciences) are invited to participate into the 2nd Sino-Finn Life Science Forum in Finland in an effort to enhance successful research collaboration between Finnish and Chinese research groups and to give a firm bases to student exchange programmes between the two countries. This event provides a good opportunity for Chinese Principal Investigators to familiarize themselves with the international level biochemical, biotechnological and biomedical research that is conducted in the Finnish research groups within the Biocenter Finland Research Organisation. The one week’s programme will include a scientific symposium in Helsinki, visits to Finnish research groups, and a visit to Karolinska Institutet in Stockholm, Sweden.

Sino-Finn Symposium 2009 in Helsinki
A whole-day symposium 24.8.2009, starting at 9 am in Viikki, Info Center, Auditorium 2 (Viikinkaari 11). A buffet available at the end of the Symposium at 4 pm. See the program here.

ENTATIVE PROGRAM Sunday, August 23 Arrival in Helsinki, Finland.
- accommodation arrangements Monday, August 24   2nd Sino-Finland Life Science Forum in Helsinki
- keynote speakers from Finland and China
See the program here >>> Tuesday, August 25 Visits to research institutes in Helsinki.
Ferry cruise to Stockholm, arrival on Wednesday morning.    Wednesday,  August 26 Visit to Karolinska Institutet in Stockholm. 
Ferry cruise back to Helsinki, arrival on Thursday morning. Thursday, August 27 Visits to research groups in Finland.
- each PI chooses the groups based on his/her interests Friday, August 28  Research group visits continue.
- returning to Helsinki and to China More detailed programme will be available later. The programme will, to some extent, be tailored according to research areas and interests of the participating PI’s.

转

    10月29日，由苏州大学系统生物学中心主办的第一届中国-芬兰生命科学论坛(苏州)在苏州红楼会议中心隆重召开。中国芬兰两国的生命科学家相聚在风景如画的 古城苏州，举办第一届中芬生命科学论坛、畅谈生命科学前沿、探索生命科学难题。苏州大学张学光副校长以及系统生物学研究中心、医学部、生物技术研究所等有关单 位的负责同志出席了会议。



    这次会议是两国科学家的第一次国家层面上的科学家面对面的交流，会议将在武汉、苏州和上海三地进行， 是中芬生命科学家的一次盛会，参加第一届中国-芬兰生命科学论坛（苏州）的芬兰方代表包括研究生院负责人、教授和博士生18名，分别来自芬兰的赫尔辛基、 图尔库、坦佩雷、奥卢等主要城市的生物研究中心。其中包括芬兰著名的系统生物学学家、赫尔辛基生物技术和分子生物学研究生院的Jussi Taipale 教授； 赫尔辛基生物技术和分子生物学研究生院院长、细胞生物学家Pekka Lappalainen 教授；赫尔辛基大学维克（Viikki）生命科学研究生院院长、病毒生物学家Dennis Bamford教授。中方代表有苏州大学数学学院、系统生物学研究中心、医学部、生物技术研究所，以及武汉大学、同济大学的师生共80多名。苏州论坛的论 题为“癌症、免疫和系统生物学” 。

    自从人类基因组计划实施以来，生命科学的发展日新月异，面对复杂的生命现象，国际间的大协作、不同学科背景的共同攻关已成为攻克生命科学难题的必要手段。 苏大为此整合组建了医学部以促进协作研究，成立了系统生物学中心，其宗旨在于促进不同学科的交叉交流，共同攻关。

    中国的生命科学目前正在走向国际化、走向国际研究的前沿，加上生命科学研究本身的复杂性， 使得我们的生命科学研究不可能闭门造车、必须与国际一流的学术团体进行深入交流，包括学术讨论、学术互动，共同申请经费、共同解决难题。 在相互学习和取长补短、相互合作和切磋的基础上， 共同提升和发展。



  


大会报告议程

8:30-9:00

Opening session chaired by SHEN Bairong

Opening ceremony

Chair:  SHEN Bairong

Opening Remark by ZHANG Xueguang

Opening Remark by Pekka Lappalainen

 

9:00-9:30

Photo session

 

 

Section 1: Chair Dennis Bamford

 

9:30-10:15

Jussi Taipale, Helsinki Graduate School in Biotechnology and Molecular Biology

Analysis of Hedgehog signaling pathways by systems biology

 

10:15-10:45

Haiyun Wang, School of Life Science, Tongji University

Clinical information driven ensemble clustering for inferring robust tumor subtypes

 

10:45-11:00  Coffee break

 

Section 2: Chair Pekka Lappalainen

 

11:00-11:30

Kati Waltering , Tampere Graduate School in Biomedicine and Biotechnology

Identification of androgen receptor (AR) target genes putatively involved in the emergence of hormone-refractory prostate cancer.

 

11:30-12:00

Alfonso Urbanucci, Tampere Graduate School in Biomedicine and Biotechnology  ChIP on sequencing using LNCaP cells overexpressing AR   

 

12:00 - 12:30 

Bairong Shen, Center for systems biology Soochow Univeristy

Computational models for disease associated amino acid mutations and mutated biological systems

 

12:30-13:30 Lunch

 

Section 3: Chair Tero Ahola

 

13:30-14:15

Xueguang Zhang: Institute of Biotechonology, Soochow University.

Cancer immunoediting and costimulatory molecules

 

14:15-14:45

Noora Kotaja, Turku Graduate School of Biomedical Sciences

Control of male germ cell differentiation by small regulatory RNAs

 

14:45-15:15

Fang Li, Institute of Biotechonology, Soochow University

The Characteristics of Placate Derived Stem Cells

 

15:15-15:30 Coffee break

 

Section 4: Chair Minna Taipale

 

 

15:30-16:00

Hanna Ollila, Helsinki Graduate School in Biotechnology and Molecular Biology Genetic background of sleep and depression

 

16:00-16:30

Songguang Ju, Institute of Biotechonology, Soochow University

4-1BBL reverse signaling and monocytic leukemia

 

16:30-17:00

Concluding session chaired by ZHANG Xueguang (SINO)

Concluding remarks by Dennis Bamford (FINN) ＆ Bairong Shen (SINO)

 

The Fourth Chinese Association of Life Science in Finland (CALSIF) Annual Meeting

University of Helsinki, Helsinki
October 31, 2009



Meeting Place:

Cajsa Room, 4th floor, Mannerheimintie 5 B, Helsinki

Contact information:

GSM 0440275578 Cheng Fang GSM 0405277708 Li Songping

Scientific Program

SATURDAY (31.10.2009)

9:30 -9:55         Registration and coffee

9:55 - 10:00     Opening remarks 


10:00-10:15     Zong Gang: Introduction of the Chinese policies to attract back oversea scholars

10:15-10:30     Tian Li: Neuronal regulation of immune responses in the central nervous system

10:30-10:45     Wu Jianmin: PINA: an integrated network analysis platform for protein-protein interactions

10:45-11:15      Interactive session with refreshments

11:15-11:30      Deng Xianbao: Tobacco Rattle Virus RNA1 as a vector to induce gene silencing on plants

11:30-11:45      Yu liying: Death pathways activated in the neurotrophic factor-deprived neurons

11:45-12:00      Cheng Fang: Functional genomics for understanding KSHV pathobiology

12:00-12:15      Zeng Zhao: Genome-wide RNAi screen identifies "CTV" as a novel

player in BMP signalling pathway 12:15-13:15 Presentations of other participants and discussion 13:15-13:30 Participants photography 13:30-14:30 Lunch 14:30-Closing of the meeting

Chinese Association of Life Science in Finland

November 25, 2006,Tampere,  Finland

9:30–10:00       Registration

10:00–10:05  Opening remarks (He Qiushui)

10:30-12:30 Session I (Chairman: Li Songping)

Academic presentations

10:30  Zhu Lei, Helsinki University: Detection of molecular forms of Prostate Specific Antigen

11:00  Fan Yuemei, Tampere  University: Hepatic lipase gene variation is related to coronary reactivity in healthy young men.

11:30   Wei Gonghong, Helsinki University: p38 signaling to chromatin modulates the induction of gamma-globin gene expression by apicidin in human erythroid cells

 

12:00 Chen Shangjun, Tampere University: Drosophila Sex-peptide and the stimulation of innate immune system

 

12:30-12:35 Participants photography

12:35-13:30 Lunch

13:30-16:30   Session II (Chairman: He Qiushui)

Research description of the CALSiF members and discussion of Cooperation with Suzhou and other universities (Select and organize delegation for the visiting and cooperation)

13:30-13:40 About cooperation with Suzhou (Shen Bairong)

13:50-16:30 Ten minutes of each presentation (every one should prepare a powerpoint presentation and it should include the significance of the research and perhaps the status of this research in China, what (projects) you would like to offer for the cooperate with China in future)

......

Fang Cheng: siRNA screening of KSHV

Ge Shichao: The Examination of Salmonella seriovr Enteritidis Genes during Infection of Human Monocytic U937 Cells using Microarray and Real Time RT-PCR

He Qiushui: Resurgence of a Vaccine Preventable Disease Pertussis in Immunized Populations

Hui Nan: open

Li Songping: Application of tandem affinity purification(TAP) method in the study of cell signaling

LIN FENG: open

Shen Bairong: Bioinformatics market

Yang Ying: Open

ZENG ZHAO: open

          .......

 

 

16:30-16:45    Coffee

16:45-17:30   Session III (Chairman : Shen Bairong)

Summary of CALSiF and its board election

17:30          Closing remarks