Medical Inflammation Research at Karolinska Institutet in Stockholm is looking for 2 excellent postdocs at the area of 1) Redoxregulation of autoimmune inflammation and 2) Immunespecific vaccination strategies using animal models. Deadline for the application is November 20, 2011.
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Post-doctoral PhD and student positions are available in the Finnish Centre of Excellence in Cell-Extracellular Matrix Research at Biocenter Oulu. We are looking for enthusiastic and skilful post-doctoral candidates with a PhD degree in life sciences or an MD-PhD degree. Closing date for applications is December 2, 2011.
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Open position for a research assistant at the University of Eastern Finland, Kuopio

Applications are invited for a 0.5-year full-time position within research group under
the supervision of Dr Leonid Yavich.

The research fellow will make electrophysiological experiments in mice, studying the
effects of drugs on electrical activity of brain. Prior experience in managing of small
laboratory animals and stereotaxic surgeries is an advantageous. Research fellow will
also acquire skills in modern neurochemical research (including in vivo voltammetry).

The positions would suit applicants with MSc in biotechnology, pharmacy, pharmacology,
neuroscience or a related discipline, and is available immediately.

Applicants should send a CV to Dr Leonid Yavich (leonid.yavich@uef.fi, tel: +358 40
5677997).
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BCO-DP invites applications for 13 doctoral training positions for 2012-2015, funded by the Ministry of Education and Culture. The positions are available from the 1st of January, 2012, for postgraduate students wishing to conduct research completing in PhD degree in one of the Biocenter Oulu projects ongoing in 2012-2015. Deadline for the applications is Friday, November 11th 2011, at 15.00 PM local time.
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Graduate student position in developmental biology is available at the Institute of Biotechnology, University of Helsinki. We are looking for an individual interested in developing highly innovative research projects on the TGF-beta type signaling in Drosophila development. The deadline for application is November 15, 2011.
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A graduate student position is open in tumor genomics group (PI Lauri A. Aaltonen) at Biomedicum, University of Helsinki. We are looking for a genetics major who has finished his/hers M.Sc.  studies, or is about to graduate soon. The applicant should be motivated, hardworking, have good interpersonal skills, and, preferably, have experience in laboratory work. Work would start as soon as possible, optimally in the beginning of December. We are accepting applications until 18.11.2011.
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PhD student and post-doctoral positions are available in the Finnish Centre of Excellence in Cell-Extracellular Matrix Research at Biocenter Oulu. We are looking for enthusiastic and skilful post-doctoral candidates with a PhD degree in life sciences or an MD-PhD degree. Closing date for applications is December 2, 2011.
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A PhD student position is available in the University of Helsinki, Cancer Gene Therapy Group (CGTG). CGTG is part of Molecular Cancer Biology Research Program, Haartman Institute and FIMM at the University of Helsinki and is located in Biomedicum Helsinki on the Meilahti campus. Our research focuses on developing oncolytic viruses for treatment of cancer. (1.11.2011)
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A graduate student position is open in tumor genomics group (PI Lauri A. Aaltonen) at
Biomedicum, University of Helsinki. We are looking for a genetics major who has finished
his/hers M.Sc.  studies, or is about to graduate soon. The applicant should be motivated,
hardworking, have good interpersonal skills, and, preferably, have experience in
laboratory work. Work would start as soon as possible, optimally in the beginning of
December.

Our work focuses on cancer and tumor genetics, especially on the inherited predisposition
to cancer. We have several dynamic projects on various cancer types utilizing state of
the art methods in genetics research.  We actively collaborate with Finnish and foreign
researchers and our group is part of the Finnish Centre of Excellence in Cancer Genetics
Research.

Recent publications:
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine
leiomyomas.
Mäkinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ, Gentile M, Yan J, Enge M,
Taipale M, Aavikko M, Katainen R, Virolainen E, Böhling T, Koski TA, Launonen V, Sjöberg
J, Taipale J, Vahteristo P, Aaltonen LA.
Science. 2011 Oct 14;334(6053):252-5. Epub 2011 Aug 25.

Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin
lymphoma.
Saarinen S, Aavikko M, Aittomäki K, Launonen V, Lehtonen R, Franssila K, Lehtonen HJ,
Kaasinen E, Broderick P, Tarkkanen J, Bain BJ, Bauduer F, Ünal A, Swerdlow AJ, Cooke R,
Mäkinen MJ, Houlston R, Vahteristo P, Aaltonen LA.
Blood. 2011 Jul 21;118(3):493-8. Epub 2011 May 11.

More on our research group:
http://research.med.helsinki.fi/gsb/aaltonen/

We are accepting applications until 18.11.2011.

Contact for further inquiries and send applications with CV to:
Docent Pia Vahteristo, PhD
tel. 191 255600
email pia.vahteristo@helsinki.fi
and/or
Outi Kilpivaara, PhD
tel. 191 25599
email outi.kilpivaara@helsinki.fi
and/or
Academy Professor Lauri A. Aaltonen; MD, PhD
tel. 191 25595
emaillauri.aaltonen@helsinki.fi
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A postdoctoral position is available at the University of Eastern Finland, Institute of
Biomedicine, Kuopio Campus, to study the molecular basis of DNA replication in human
cells.

The four-year position is funded by the Academy of Finland and it is available in the
group of Professor Juhani Syväoja. The group studies the interplay between replicative
DNA polymerases and other replication proteins during the cell cycle in cultivated human
cells.  Multiple methods of molecular and cell biology are applied, the main technique
being chromatin immunoprecipitation (CHIP). The focus of the group’s research is
currently expanding from specific replication initiation sites to a genome wide approach
with deep-sequencing methods included.  The research facilities are excellent and the
group has good and well-functioning international collaborative relationships. Applicants
should have a strong background in bench-level molecular and cell biology. Experience of
chromatin immunoprecipitation methods will be regarded as a merit and readiness for
co-supervision of PhD students is desirable.

A person to be appointed as a postdoctoral researcher shall hold a suitable doctoral
degree. In an ideal case the four-year position starts on January 1st, 2012. Later dates
are possible, but would shorten the four-year period. The salary will be based on the
salary system of the Finnish universities. The salary is placed on level 5 (€2714.54).
The total salary is comprised of a job requirement component and a personal performance
component. The personal performance component can comprise a maximum of 46.3% of the job
requirement component.

The written application containing 1) a cover letter indicating the applicant’s previous
achievements and motivation for this research, 2) the applicant’s CV with publications,
and 3) the contact information of two professional referees, including the applicant’s
current supervisor, should be sent to the registry office of the Joensuu or Kuopio
Campus: Postal addresses: University of Eastern Finland, Registry office, P.O. Box 1627,
70211 Kuopio or University of Eastern Finland, Registry office, P.O. Box 111, 80101
Joensuu. The application should also be e-mailed to Professor Juhani Syväoja,
juhani.syvaoja@uef.fi

The deadline for applications is November 4th, 2011 at 15:00 (3 pm Finnish time).

For further information please contact Professor Juhani Syväoja, juhani.syvaoja@uef.fi

Selected references:

Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, di Cicco G,
Markkanen E, Syväoja JE, Tanguy Le Gac N. (2011) In Vitro Gap-directed Translesion DNA
Synthesis of an Abasic Site Involving Human DNA Polymerases epsilon, lambda, and beta. J
Biol Chem. 286, 32094-104

Locatelli GA, Pospiech H, Le Gac N, Hubscher U, Parkkinen S,  Syväoja JE, Villani G.
(2010) Effect of 8-oxo-guanine and abasic site DNA lesions on in vitro elongation by
human DNA polymerase ε in presence of Replication Protein A and Proliferating Cell
Nuclear Antigen, Biochem J. 429, 573-582

Nuutinen, T., Tossavainen, H., Fredriksson, K., Pirilä, P., Permi, P., Pospiech, H., and
Syvaoja, J.E.  (2008) The solution structure of the amino-terminal domain of human DNA
polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins, Nucl Acids Res.
36, 5102-5110.
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Medical Inflammation Research at Karolinska Institutet in Stockholm is looking for 2
excellent postdocs at the area of 1) Redoxregulation of autoimmune inflammation and 2)
Immunespecific vaccination strategies using animal models.

Deadline for the application is 20th of Nov and can be applied on-line at KI homepage
http://jobb.ki.se or through Nature jobs
http://www.nature.com/naturejobs/science/jobs/224356-Post-doctoral-position-in-Redoxregulation-of-autoimmune-inflammation

http://www.nature.com/naturejobs/science/jobs/224357-Post-doctoral-position-in-Immunespecific-vaccination-strategies-using-animal-models

More detailed information can be found below.

*********************************************

Karolinska Institutet
is looking for a
2 post doctoral positions

Workplace: Department of Medical Biochemistry and Biophysics
Form of employment: Fixed term employment with possibility to extension
Scope: Full-time
Time period: Duties wish to be taken as soon as possible
Description of the work group/equivalent and its work/focus:

We invite applications for two post doctoral positions at our department.
One position in Redoxregulation of autoimmune inflammation and one position in
Immunespecific vaccination strategies using animal models.

Both positions will be placed at the Division of Medical Inflammation Research (see
http://www.inflam.mbb.ki.se)
Area of responsibilities/duties:

1) Post doctoral position in Redoxregulation of autoimmune inflammation.

A post doctoral position is now open for a highly motivated scientist with a strong
background in experimental immunology and inflammation models. The project will focus on
the role of antigen-presenting cells regulating T cell immunity through oxidative burst
will be investigated. The Ncf1 gene has been positional cloned to be a major gene
regulating autoimmune arthritis and we have found the gene regulate both macrophage and T
cell reactivity. To sort out the underlying mechanisms operating in vivo we have made new
mouse strains conditionally expressing the Ncf1 gene. The project will use these strains
to study the role of Ncf1 in different antigen-presenting cells.


2) Post doctoral position in Immunespecific vaccination strategies using animal models.

A post doctoral position is now open for a highly motivated scientist with a strong
background in cellular immunology and experimental animal work. The project will focus on
immune tolerance in experimental animal models. In the MIR lab we have developed new
strategies for therapeutic vaccination leading to protection against arthritis. It is
based on the discovery of critical posttranslationally modified peptides. The project
will aim to understand the underlying specificity and mechanism of the vaccination
effect. Various specifically designed mouse strains will be used.

NOTE: Please state in your application which position you are applying for.
Qualifications: To qualify, the applicant must hold a doctor’s degree or a foreign
qualification deemed equivalent to a doctorate in the field of medicine, biomedicine or
biology. 



Postgraduates who have yet to graduate may apply if their public defense is scheduled to
take place within three months after the application deadline, in which case verification
from the Dissertation Committee or equivalent body must be submitted with the
application.



Experience of research work in experimental animal of rodents, and in cellular immunology
is needed. The candidate must also have knowledge in statistics. Fluency in English is a
requirement.



The positions are available for 2 years and have the possibility to be prolonged.Duties
wish to be taken as soon as possible.

Contact: Professor Rikard Holmdahl
+46-8-524 846 07
rikard.holmdahl@ki.se

Union representatives
Biborka Bereczky Veress, SACO
+46 701-73 85 75
biborka.bveress@ki.se
 Anna Aleman, OFR
+46 8 524 866 07
anna.aleman@ki.se
 Gunnar Stenberg, SEKO
+46 8 524 880 75
gunnar.stenberg@ki.se
Application procedure: Application sent to: Our online application service:

Apply directly via KI Job:
http://jobb.ki.se/internal/application/jobApplication.asp?adId=6211

or
Karolinska Institutet
Department of Medical Biochemistry and Biophysics
171 77 STOCKHOLM
email: rekrytering@mbb.ki.se
Reference number: 6009/2011 Last date for applications: November 20th 2011

Karolinska Institutet is one of the world´s leading medical universities. Its mission is
to contribute to the improvement of human health through research and education.
Karolinska Institutet accounts for over 40 per cent of the medical academic research
conducted in Sweden and offers the country´s broadest range of education in medicine and
health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the
Nobel laureates in Physiology or Medicine.

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Research Scientist, Nonclinical Safety Assessment
Orion Corporation, Orion Pharma, Espoo

The role of Nonclinical Safety Assessment, R&D, is to predict and ensure the safety of
new chemical entities during various phases of drug development. In discovery phase it is
important to exclude molecules with toxic properties when selecting drug candidates for
further development. We support the drug research and development at all Orion’s core
therapy areas.

Your key responsibilities are to validate our new in vitro cytotoxicity assay and to
develop the result analyses of the assay. You will use an automated fluorescence
microscope to measure multiple cytotoxicity parameters (high content analysis). You will
validate the method by using reference compounds and develop data analyses with data
processing and visualization programs (e.g. Spotfire). In addition, you will find out and
resolve toxicity mechanism by using in vitro techniques.

The position is temporary (maternity leave) starting from 1.1.2012 and lasting about one
year.

You have preferably PhD level degree in biochemistry, cell biology, bioinformatics or
related field, and you have several years’ expertise in research work. We expect that you
have deep experience in cell biology and in fluorescence microscopy and / or in analyzing
of large biological datasets. In addition, experience on image analyses, method
validation and multiparameter-HTS/HCS (high throughput / high content screening)
–techniques are regarded beneficial.

We expect our research scientist to be able to work both independently and in
multidisciplinary research teams. You have strong IT-skills and are familiar to work with
data handling software. Innovation and consistency are the features you need, when you
develop and validate methods. Excellent oral and written communication skills in English
are a must.

We offer challenging and interesting position in drug research as a member of
multi-disciplinary team in modern facilities.

Additional information on the position: Leena Sopanen, tel. 010 426 3632 (on 25th October
or 27th October at 10.00-11.00).

Application period ends 1.11.2011.

Please fill the electronic application at Orion webpage:
https://careers.fi/orion/add_application.cgi?job_id=894



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PhD student position in developmental biology is available at the Institute of
Biotechnology, University of Helsinki.

We are looking for an individual interested in developing highly innovative research
projects on the TGF-beta type signaling in Drosophila development. The current research
focus includes; 1) patterning and morphogenesis of wing veins regulated by BMP signaling,
and 2) analysis of BMP morphogen gradient dynamics in the embryo. Our recent findings
indicate that spatial distribution of BMP type ligand in Drosophila wing vein development
is tightly regulated by a combination of long-range facilitated transport mechanism and
short-range active retention mechanism.

The prospective project is to understand the molecular mechanisms behind the mobility
(long-range) and immobility (short-range) of signaling molecules are coordinated in the
same tissue. Since the research projects include the fields of Drosophila genetics,
molecular biology, biochemistry, imaging analysis and high throughput approach such as
gene expression profile analysis, they offer an interdisciplinary environment for
research training.

Applicants are invited from candidates who have a background in developmental biology,
genetics, and molecular biology. Further enquiries regarding the scope and details of the
projects should be addressed to: osamu.shimmi@helsinki.fi or visit
http://www.biocenter.helsinki.fi/bi/shimmi/.

The deadline for application is November 15, 2011.

Please send a cover letter and CV including contact information for two references to:
Osamu Shimmi, Ph.D
Developmental Biology Program
Institute of Biotechnology
University of Helsinki
P.O. Box 65 (Viikinkaari 1)
00014 Helsinki, Finland
E-mail: osamu.shimmi@helsinki.fi
www.biocenter.helsinki.fi/bi/shimmi/