INFO1

We are looking for a motivated postdoctoral scientist interested in cell biology.

The post offers the possibility to concentrate on one or two topics: either lysosome
biology (especially the lysosomal membrane protein LAMP-2), or on autophagy (especially
the early steps of autophagosome formation). The first alternative would require
experience on cell biological/biochemical methods, while the latter alternative would
suit better for a person with experience and interest in microscopical methods, including
light and electron microscopy. Experience in recombinant DNA technology would be helpful
in both topics. Our laboratory is located in the Department of Biosciences, University of
Helsinki, at the Viikki campus. The campus houses several bioscience departments and
research institutes and excellent core facilities for microscopy and other relevant
techniques (http://www.biocenter.helsinki.fi/index.html).

To apply, please send your CV and an application letter clearly describing your previous
achievements in the field, to: eeva-liisa.eskelinen(at)helsinki.fi. Also include names
and contact information of three references. Applications are welcome until the position
is filled. The post is initially for one year.

More information:
-http://www.helsinki.fi/biosciences/biochemistry/eskelinen
-https://tuhat.halvi.helsinki.fi/portal/en/persons/eevaliisa-eskelinen%28f08cf28b-cbdb-4e20-913a-149ca6ab8906%29.html
-eeva-liisa.eskelinen(at)helsinki.fi

Recent references:
*Eskelinen E-L, Saftig P: Autophagy: A lysosomal degradation pathway with a central role
in health and disease. BBA Mol Cell Res 2009; 1793:664-673
*Schneede A, Schmidt CK, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M,
Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen E-L: Role
for LAMP-2 in endosomal cholesterol transport.  J Cell Mol Med 2011, 15:280-295
*Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen E-L: 3D tomography reveals connections
between the phagophore and endoplasmic reticulum. Autophagy 2009; 5:1180-1185

INFO 2

Graduate student or Postdoc position at University of Tampere is open for applications.

The interest of the group is the immunological mechanisms by which allergic inflammation
is initiated, amplified and down-regulated/controlled. Experience on using laboratory
animals not required but considered as beneficial. Likewise, experience on using
multi-color flow-cytometry is considered beneficial. The salary will be in accordance
with the University of Tampere salary system (YPJ).

Applications (preferably a single PDF file) should be sent to: ilkka.junttila@uta.fi by
16.5.2011 and they should contain short CV, contact information of two or three
references, a short description of prior research experience/achievements and future
scientific goals.

Further information from: ilkka.junttila@uta.fi


INFO 3

The IGBMC is one of the leading European centers for biomedical research, providing an
outstanding research and training environment. The IGBMC is committed to train students
in all areas of structural, molecular and cellular biology with relevance to development,
physiology and disease, and expose them to leading edge technology developments.

IGBMC’s PhD Programme is based on a three year - intensive training which comprises
dedicated research investigations and active participation in diverse lectures and
practicals.  Close collaborations with other research institutions in the “Parc
d’Innovation” such as the adjacent MCI (Mouse Clinical Institute), the trinational
biotechnology school ESBS (Ecole Supérieure de Biotechnologie Strasbourg ), the Faculty
of Pharmacy as well as ISIS (Institut de Science et d'Ingénierie Supramoléculaires ) and
the University of Strasbourg at large, contribute to synergistic and collegial
interactions within and beyond IGBMC. Concomitantly with the highly cosmopolitan and
dynamic nature of Strasbourg, our 280 students and post-doctoral fellows from over 30
distinct countries represent a key driving force of IGBMC international visibility.

After the past success of the last three years, IGBMC is most pleased to announce the
IGBMC International PhD Programme 2011-2012 call for students. Application deadline is
April 30th 2011.

More information may be found on the web site :
http://www.igbmc.fr/formation/phd-program/index.html


INFO 4
Postdoctoral fellow/PhD position in cancer biology

A post-doctoral fellow/PhD position is available in the laboratory of Jukka Westermarck
at the Centre for Biotechnology (CBT), University of Turku, Turku, Finland
(http://www.btk.fi/research/research-groups/westermarck/). CIP2A is a novel clinically
relevant human oncoprotein recently identified by our laboratory (Junttila, et al., Cell,
130, 2007). Current results clearly indicate that CIP2A might be a potential target
protein for future cancer therapies. At the molecular level CIP2A functions as an
inhibitor of an essential protein phosphatase complex PP2A, but the molecular mechanisms
regulating CIP2A interaction with PP2A or PP2A complex assembly in cancer cells are very
poorly understood.

The aim of the project is to develop novel fluorescent reporters for studying PP2A
complex assembly and CIP2A function. The future prospect of the work is to use these
reporters for high-throughput screening of small molecule compounds regulating PP2A and
CIP2A functions. The work will be done in collaboration with Dr. Daniel Abankwa´s
laboratory (CBT, Turku), who is using cutting-edge cellular imaging (Fluorescence
Lifetime Imaging Microscopy, FLIM, and STED-nanoscopy), high-throughput methodological
approaches (high-content and cytometer chemical- and RNAi-screening) to study cancer
signaling. Position is available immediately and candidates will be considered until the
positions are filled. Position is initially for two years with a possibility to extension
depending on the progress of the project.

Centre for Biotechology, University of Turku is a top-quality research center harbouring
excellent core facilities for bioimaging, proteomics, genomics and crystallography. At
the center works several research groups with distinguished publication profile in world
leading journals (http://www.btk.fi/home/main/). Turku is a beautiful old city located in
South-Western corner of Finland surrounded by a magnificient archipelago with thousands
of small islands (http://www.saaristo.org/eng/).

We are looking for hard-working and ambitious candidates with proven track record of
successful scientific work. Solid previous experience on bioimaging and use of advanced
microscopy techniques will be a clear asset. To apply, send to dabankwa@abo.fi,
preferably as one merged pdf: your CV and an application letter clearly describing your
previous achievements in the field and especially your experience on use of advanced
microscopy techniques. Also include names and contact information of three references.

Recent publications:

Junttila et al.,: Cell, 130, 51–62, 2007.
Wu et al.,: Nature Methods, 6, 75-77, 2009
Khanna et al.,: Journal of the National Cancer Institute, 101, 793-805, 2009.
Abankwa et al.,: Embo J., 27, 727-735, 2008
Abankwa et al.,: PNAS, 107, 1130-1135, 2010.


INFO 5

The Institute of Biotechnology, University of Helsinki has positions open for 2 PhD
students to work on projects studying how the flow of cellular information is altered in
cancer. Particular focus will be put on using quantitative mass spectrometry to identify
the molecular context in which cancer-linked proteins such as kinases, phosphatases, and
transcription factors function.

Interested and highly motivated students that are enthusiastic about the prospect of
driving forefront research in an international environment are encouraged to apply. A
strong background in biochemistry and molecular biology is an asset. Preliminary
experience in cancer biology and/or proteomics would be advantageous, but not necessary.
Good written and spoken English as well as the desire to work in a team-oriented
environment are required.

The Institute of Biotechnology (BI) at the University of Helsinki is an independent
research institute located at the Viikki Campus, where it forms part of the largest
national life sciences alliance in Finland. The Institute provides excellent facilities
to conduct interdisciplinary research in biochemistry and molecular biology. In addition,
close collaborations with other groups at the Institute, in Meilahti campus and research
institutes abroad are in place.

For further information about the open positions, please contact Group Leader Markku
Varjosalo (markku.varjosalo@helsinki.fi).

Applications are accepted until June 17, 2011. But, earlier application is encouraged;
the interview process will begin as soon as a competitive application is received.

Please send your application and CV as one single document (pdf) to
markku.varjosalo@helsinki.fi

Please remember to include the names and contact information of two references.

Recent publications:

Varjosalo et al., Dev Cell. 2006 Feb;10(2):177-86
Björklund et al., Nature. 2006 Feb 23;439(7079):1009-13
Varjosalo et al., Cell. 2008 May 2;133(3):537-48
Varjosalo et al., Genes Dev. 2008 Sep 15;22(18):2454-72
Sugiyama et al., Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15786-91
Sugiyama et al., Cancer Res. 2010 Oct 15;70(20):7851-61

INFO 6

Manager position open at the Institute of Biotechnology (University of Helsinki) Protein
Chemistry and Proteomics Facility (PCPF)

The Institute of Biotechnology Protein Chemistry and Proteomics Facility  (PCPF) provides
Finnish researchers access to unparalleled mass spectrometric equipment, state-of-the-art
protein and peptide separation equipment that can be applied to a wide variety of low- to
high-throughput analyses. Work involves developing and managing the analysis equipment
and computational infrastructure of PCPF. Protein Chemistry and Proteomics Facility is
situated at the Institute of the Biotechnology, University of Helsinki Viikki Campus. The
PCPF is located adjacent to the research group headed by Dr. Varjosalo.

The successful candidate will work under the Head of the Facility, Dr. Markku Varjosalo,
to develop, manage and maintain the equipment infrastructure of PCPF. In addition, he or
she will plan and implement new automation, sample analysis and data analysis pipelines.

Qualifications
The applicants should have a minimum of Masters degree or equivalent in chemistry,
biochemistry or engineering sciences. A Ph.D. and postdoctoral training are considered a
benefit. Experience in developing or operating mass spectrometry instruments and analysis
techniques, and good communication in English is required. Individuals interested in
combining the work with advanced studies will also be considered.

Please send your application, CV and two letters of reference as a single document (pdf)
to reach us by no later than 27th May, 2011 by e-mail to protchem-applications@helsinki.fi

For further information about the institute
http://www.biocenter.helsinki.fi/bi/about/index.html