Position this week 20-26/12/2010

来源：Finnbionet, VTT, FIMM, 科学网 等

20-26/12/2010 INFO 1



Postdoctoral position available at Indiana University Simon Cancer Center in Indianapolis in a laboratory that studies mechanisms of metastasis in ovarian cancer.

The project is part of a collaborative consortium investigating epigenetic modulation of platinum anti-tumor activity in animal models of ovarian cancer. Funding for this project will cover three years.

Interested individuals can contact Dr.Daniela Matei at dmatei@iupui.edu .


20-26/12/2010 INFO 2

Summer School on Modern Methods in Epidemiology and Biostatistics

We have the pleasure to announce the 2011 Edition of the Summer School on Modern Methods in Epidemiology and Biostatistics.

The School aims to provide introductory and advanced courses in medical statistics and epidemiology, and their application in etiology research
and public health.

Courses given in a two week program, will be run by faculties from Harvard School of Public Health and Karolinska Institutet.Furthermore, faculties from the University of Milano-Bicocca and  Bocconi University will join the program.

In addition, both introductory and more advanced  one-day courses on Stata  will be  offered. All courses will be using Stata.

The school will be held from June 5 to June 18 2011 at Antico Borgo di Tabiano Castello, in Parma, Italy.

Please visit the course homepage for more information about the course:
www.biostatepi.org

20-26/12/2010 INFO 3

We are looking for a motivated and proficient post doc in a new project where we characterize plant polyketide reductases (PKRs) using enzymatic and genomic approaches.

A vast array of plant secondary metabolites are synthesized through the acetate-malonate pathway, where acetate units provided by malonyl-CoA are concatenated into a polyketide intermediate which may fold in a number of ways to produce, e.g., new aromatic ring systems. The best known example of these reactions is the formation of chalcone, the first precursor of the flavonoid branch of phenylpropanoids. Chalcone synthase together with other plant polyketide synthases form a super family with a common origin in evolution but wide variation in starter substrate selection, number of iteration steps and final folding of the product. In analogy to fatty acid biosynthesis, but in a highly selective manner, the growing polyketide chain may also be reduced during its synthesis, leading to further increased chemical variation. The associated PKR is known only for chalcone synthase, but reductive steps are needed for biosynthesis of, e.g., the raspberry ketone (raspberry), the glucosidic lactones gerberin and parasorboside (gerbera), the alkaloid coniine (poison hemlock) and the naphtoquinone plumbagin (sundews). The project is a joint project between University of Helsinki and VTT. Our specific objectives are to identify and isolate genes encoding PKRs in several plants, to heterologously express the PKR genes and isolate the encoded enzymes and to functionally characterize the enzymes in combination with the relevant PKS and analyze the products. Genomic and transcriptomic resources exist for gerbera and will be developed for the other plant species. The Academy of Finland funded postdoctoral position is for 2011-2014. Suitable candidates should have an interest in plant secondary metabolism and experience in the areas of molecular biology, protein purification, enzymology and bioinformatics.

To apply, e-mail your application, CV, and contact information of two referees to teemu.teeri- at-helsinki.fi

Deadline for applications is January 15, 2011. Additional information about the research group:  teemu.teeri-at-helsinki.fi http://www.mm.helsinki.fi/mmsbl/english/research/Gerberalab/SecMetab.html

20-26/12/2010 INFO 4

The Institute for Molecular Medicine Finland (FIMM) is a partner institution of the European Molecular Biology Laboratory. FIMM is a joint venture of the University of Helsinki, the Hospital District of Helsinki and Uusimaa (HUS), the National Institute for Health and Welfare (THL) and the VTT Technical Research Centre of Finland. FIMM is currently seeking a Senior Researcher or Postdoctoral Researcher for the RNAi Unit, FIMM Technology Centre. Application deadline is December 31, 2010.






20-26/12/2010 INFO 5





A four-year post-doctoral position is available in the research group of Jukka Finne at the Department of Biochemistry and Biotechnology, University of Helsinki, Finland. The project deals with the identification of regulatory factors of polysialic acid, an important developmental cell surface antigen also associated with the malignant behaviour of cells, using novel insertion mutagenesis technology. The position is to be filled as soon as possible. Applications will be considered until a suitable candidate has been found. (9.12.2010)








20-26/12/2010 INFO 6




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